Nebido 1000 mg 4 ml solution for injection Patient Information Leaflet PIL emc

Androgen treatment and certain cancers has been found in studies on laboratory animals. Athletes treated for testosterone replacement in primary and secondary male hypogonadism should be advised that the medicinal product contains an activesubstance which may produce a positive reaction in anti-doping tests. Cases of benign and malignant liver tumours have been reported in users of hormonal substances such as androgen compounds. If severe upper abdominal complaints, liver enlargement or signs of intra-abdominal haemorrhage occur in men using Nebido, a liver tumour should be included in the differential-diagnostic considerations. Your doctor will measure your testosterone levels before and at the beginning of treatment.

Normal Testosterone Levels

The delivery method is what makes Nebido injections such an effective way to raise testosterone in the body. The reason for this is the fact that injections are the most direct route to get testosterone in the bloodstream. In a Nebido injection, you’ll find that the injection site creates a natural reservoir of testosterone that slowly disperses throughout the weeks to provide an evenly-balanced treatment that won’t fizzle out after a few days. After the administration of radio-labelled testosterone, about 90% of the radioactivity appears in the urine as glucuronic and sulphuric acid conjugates and 6% appears in the faeces after undergoing enterohepatic circulation.

• Serum levels below normal range would indicate the need for a shorter injection interval.
• Local guidelines for safety monitoring under testosterone replacement therapy should be taken into consideration.
• Nebido 1000mg/4 ml exerts a negative feedback mechanism on pituitary release of LH and follicle-stimulating hormone (FSH).
• Treatment is usually supportive, e.g. by administration of supplemental oxygen.
• In 2013, a study aimed to evaluate the efficacy of testosterone undecanoate therapy on bone mineral density (BMD) and biochemical markers of bone turnover in elderly males with osteoporosis and low serum testosterone levels.

Start of treatment

Your doctor or medical professional will show you the details, but you should know that testosterone nebido is very easily given with just an injection. Testosterone which is generated by ester cleavage from testosterone undecanoate is metabolised and excreted the same way as endogenous testosterone. The undecanoic acid is metabolised by ß-oxidation in the same way as other aliphatic carboxylic acids. The major active metabolites of testosterone are oestradiol and dihydrotestosterone.

While some men might notice slight improvements within a few weeks, it typically takes 2-3 months to achieve optimal testosterone levels and experience the full benefits of NEBIDO. A healthy lifestyle plays a crucial role in optimizing testosterone levels and maximizing the benefits of TRT. Maintaining a balanced diet rich in fruits, vegetables, and whole grains provides the body with essential nutrients for testosterone production.

There is limited experience of the use of Nebido in elderly patients over 65 years of age. However, it should be taken into account that physiologically testosterone serum levels are lower with increasing age. Testosterone replacement therapy for male hypogonadism when testosterone deficiency has been confirmed by clinical features and biochemical tests (see section 4.4).

Each ml of solution contains 250 mg testosterone undecanoate equivalent to 157.9 mg testosterone. ►    blood-thinning tablets (coumarin derived oral anticoagulants) since this can increase the risk of bleeding. There is no data available on the use of Nebido in males under 18 years of age.

After 3-4 weeks of daily system use, blood should be drawn 2-4 hours after system application for determination of serum total Nebido 1000mg/4 ml. Nebido 1000mg/4 ml is a steroid sex hormone found in both men and women. In men, Nebido 1000mg/4 ml is produced primarily by the Leydig (interstitial) cells of the testes when stimulated by luteinizing hormone (LH).

We do not guarantee the accuracy or completeness of the information regarding medications, medical preparations, or contact details of pharmaceutical companies and medical facilities. There is a pre-scored mark beneath the coloured point on the ampoule eliminating the need to file the neck. Prior to opening, ensure that Methyldrostanolone any solution in the upper part of the ampoule flows down to the lower part. Use both hands to open; while holding the lower part of the ampoule in one hand, use the other hand to break off the upper part of the ampoule in the direction away from the coloured point.